Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Evidential Uniqueness is the thesis that, for any batch of evidence, there’s a unique doxastic state that a subject with that evidence should have. One of the most common kinds of objections to views that violate Evidential Uniqueness are arbitrariness objections – objections to the effect that views that don’t satisfy Evidential Uniqueness lead to unacceptable arbitrariness. The goal of this paper is to examine a variety of arbitrariness objections that have appeared in the literature, and to assess the extent (...) to which these objections bolster the case for Evidential Uniqueness. After examining a number of different arbitrariness objections, I’ll conclude that, by and large, these objections do little to bolster the case for Evidential Uniqueness. (shrink)

This volume brings together a range of influential essays by distinguished philosophers and political theorists on the issue of global justice. Global justice concerns the search for ethical norms that should govern interactions between people, states, corporations and other agents acting in the global arena, as well as the design of social institutions that link them together. The volume includes articles that engage with major theoretical questions such as the applicability of the ideals of social and economic equality to the (...) global sphere, the degree of justified partiality to compatriots, and the nature and extent of the responsibilities of the affluent to address global poverty and other hardships abroad. It also features articles that bring the theoretical insights of global justice thinkers to bear on matters of practical concern to contemporary societies, such policies associated with immigration, international trade, and climate change. -/- Contents: Introduction; Part I Standards of Global Justice: (i) Assistance-Based Responsibilities to the Global Poor: Famine, affluence and mortality, Peter Singer; We don't owe them a thing! A tough-minded but soft-hearted view of aid to the faraway needy, Jan Narveson; Does distance matter morally to the duty to rescue? Frances Myrna Kamm. (ii) Contribution-Based Responsibilities to the Global Poor: 'Assisting' the global poor, Thomas Pogge; Should we stop thinking about poverty in terms of helping the poor?, Alan Patten; Poverty and the moral significance of contribution, Gerhard Øverland. (iii)Cosmopolitans, Global Egalitarians, and its Critics: The one and the many faces of cosmopolitanism, Catherine Lu; Cosmopolitan justice and equalizing opportunities, Simon Caney; The problem of global justice, Thomas Nagel; Against global egalitarianism, David Miller; Egalitarian challenges to global egalitarianism: a critique, Christian Barry and Laura Valentini. Part II Pressing Global Socioeconomic Issues: (i) Governing the Flow of People: Immigration and freedom of association, Christopher Wellman; Democratic theory and border coercion: no right to unilaterally control your own borders, Arash Abizadeh; Justice in migration: a closed borders utopia?, Lea Ypi. (ii) Climate Change: Global environment and international inequality, Henry Shue; Valuing policies in response to climate change: some ethical issues, John Broome; Saved by disaster? Abrupt climate change, political inertia, and the possibility of an intergenerational arms race, Stephen M. Gardiner; Polycentric systems for coping with collective action and global environmental change, Elinor Ostrom. (iii) International Trade: Responsibility and global labor justice, Iris Marion Young; Property rights and the resource curse, Leif Wenar; Fairness in trade I: obligations arising from trading and the pauper-labor argument, Mathias Risse; Name index. -/- See: www.ashgate.com/default.aspx?page=637&calctitle=1&pageSubject=483&sort=pubdate&forthcoming=1&title_i d=9958&edition_id=13385. (shrink)

In our reply to Rowe, we explain why most of what he criticizes is actually the product of his misunderstanding our argument. We begin by showing that nearly all of his Part 1 misconceives our project by defending a position we never attacked. We then question why Rowe thinks the distinction we make between motivational and virtue intellectualism is unimportant before developing a defense of the consistency of our views about different desires. Next we turn to Rowe’s criticisms of our (...) account of the prudential paradox and show these criticisms to rest on a misunderstanding. We close with some remarks about the implausibility and textual problems Rowe faces in denying that Socrates recognized a role for painful punishments. (shrink)

Tennenbaum's Theorem yields an elegant characterisation of the standard model of arithmetic. Several authors have recently claimed that this result has important philosophical consequences: in particular, it offers us a way of responding to model-theoretic worries about how we manage to grasp the standard model. We disagree. If there ever was such a problem about how we come to grasp the standard model, then Tennenbaum's Theorem does not help. We show this by examining a parallel argument, from a simpler model-theoretic (...) result. (shrink)

Human neural and behavioral activities have been reported to exhibit fractal dynamics known as 1/f noise, which is more aptly named 1/f scaling. Some argue that 1/f scaling is a general and pervasive property of the dynamical substrate from which cognitive functions are formed. Others argue that it is an idiosyncratic property of domain‐specific processes. An experiment was conducted to investigate whether 1/f scaling pervades the intrinsic fluctuations of a spoken word. Ten participants each repeated the word bucket over 1,000 (...) times, and fluctuations in acoustic measurements across repetitions generally followed the 1/f scaling relation, including numerous parallel yet distinct series of 1/f fluctuations. On the basis of work showing that 1/f scaling is a universal earmark of metastability, it is proposed that the observed pervasiveness of 1/f fluctuations in speech reflects the fact that cognitive functions are formed as metastable patterns of activity in brain, body, and environment. (shrink)

Physicians working in the world of competitive sports face unique ethical challenges, many of which center around conflicts of interest. Team-employed physicians have obligations to act in the club's best interest while caring for the individual athlete. As such, they must balance issues like protecting versus sharing health information, as well as issues regarding autonomous informed consent versus paternalistic decision making in determining whether an athlete may compete safely. Moreover, the physician has to deal with an athlete's decisions about performance (...) enhancement and return to play, pursuit of which may not be in the athlete's long-term best interests but may benefit the athlete and team in the short term. These difficult tasks are complicated by the lack of evidence-based standards in a field influenced by the lure of financial gains for multiple parties involved. In this article, we review ethical issues in sports medicine with specific attention paid to American professional football. (shrink)

We describe an approach that enables a more complete evaluation of the validity of emotional intelligence measures. We argue that a source of evidence for validity is often overlooked by researchers and test developers, namely, evidence based on response processes. This evidence can be obtained through a definition of the ability, a description of the mental processes that operate when a person uses the ability, the development of a theory of response behaviour that links variation in the construct with variation (...) on the responses to the items of a measure, and a test of the theory of response behaviour through one or more strategies that we describe. (shrink)

We begin by discussing some logical constraints on the psychological approach to personal identity. We consider a problem for the psychological approach that arises in fission cases. The problem engenders the need for a non-branching clause in a psychological account of the co-personality relation. We look at some difficulties in formulating such a clause. We end by rejecting a recently proposed formulation of non-branching. Our criticism of the formulation raises some interesting questions about the individuation of person stages.

Derek Parfit has offered numerous arguments in an attempt to establish that identity is not what matters. Jens Johannson has recently argued that Parfit's various arguments for the claim that identity is not what matters fail to establish what Parfit takes such arguments to establish. Johannson contends that this is due in part to the invalidity of one of Parfit's key arguments, and the fact that Parfit ignores a position that is compatible with the conclusions of his successful arguments and (...) the claim that identity is in fact what matters, namely, that I survive fission as either one of the fission products or the other, but it is indeterminate which one I survive as. I aim to establish here that both of Johannson's assertions are problematic. As a corollary of this task, I hope to shed some light on the relationship between indeterminacy and fission-based arguments for the claim that identity is not what matters. (shrink)

_ Source: _Volume 5, Issue 1, pp 55 - 60 Peter Murphy has argued that effective skeptical scenarios all have the following feature: the subject involved in the scenario does not know that some ordinary proposition is true, even if the proposition is true in the scenario. So the standard “false belief” conception of skeptical scenarios is wrong, since the belief of the targeted proposition need not be mistaken in the scenario. Murphy then argues that this observation engenders a problem (...) for skeptical arguments: they require the KK principle. We respond to this criticism on behalf of the skeptic in our paper. (shrink)

Context shapes negotiators’ actions, including their willingness to act unethically. Focusing on negotiators use of deception, we used a simulated two-party negotiation to test how three contextual variables—regulatory focus, power, and trustworthiness—interacted to shift negotiators’ ethical thresholds. We demonstrated that these three variables interact to either inhibit or activate deception, providing support for an interactionist model of ethical decision-making. Three patterns emerged from our analyses. First, low power inhibited and high power activated deception. Second, promotion-focused negotiators favored sins of omission, (...) whereas prevention-focused negotiators favored sins of commission. Third, low cognition-based trust influenced deception when negotiators experience fit between power and regulatory focus, whereas affect-based trust influenced deception when negotiators experience misfit between these structural context variables. We conclude that regulatory focus primes different moral templates: promotion-focused negotiators’ decision to deceive is determined by moral pragmatism, whereas prevention-focused negotiators’ decision to deceive is determined by opportunism. Because each combination of power and regulatory focus was tied to a specific subcomponent of trust, we further conclude that negotiators engage in motivated information search to determine whether they should deceive their opponents. (shrink)

Based on the assumption that confrontation with one’s physical reflection can be aversive, we explored the appeal of possible “escape routes” when incidentally exposed to one’s mirror image. Compared to their no-exposure peers, individuals who felt less chronically “trapped” in their bodies showed increased interest in flow experiences and decreased interest in experiences involving low-level thinking or a subjective sense of meaning when exposed to their reflection. Mirror exposure also increased overall interest in “pure consciousness events,” wherein the transcendence of (...) space and time figures centrally. The aversive effects of even implicit confrontation with one’s reflection therefore seem more diverse than anticipated based on existing frameworks such as Objective Self-Awareness theory, so additional theoretical development seems warranted. (shrink)

This chapter focuses on synaesthesia research in the 21st century. It begins by giving counts of publications and these are further broken down by type, focus, and measures used. Then, there is a review of major questions being addressed by current research in the area of synaesthesia. The amount of research being done in this area is growing rapidly, and is incorporating a number of different research approaches to address a wide variety of questions.

Buprenorphine is a form of opioid agonist treatment that has been demonstrated to be an effective medication for opioid addiction. It is available in different formulations and marketed under various trade names, including commonly as a buprenorphine/naloxone combination. This paper provides an overview of existing literature on the supply of buprenorphine treatment, the ability of people to access treatment with buprenorphine, and the quality of treatment received. We argue that better data for each of these aspects of treatment could inform (...) policy to expand effective treatment with buprenorphine, and we suggest steps to obtain and act on such data. (shrink)

Those who endorse a knowledge-first program in epistemology claim that rather than attempting to understand knowledge in terms of more fundamental notions or relations such as belief and justification, we should instead understand knowledge as being in some sense prior to such concepts and/or relations. If we suppose that this is the correct approach to theorizing about knowledge, we are left with a residual question about the nature of those concepts or relations, such as justification, that were thought to be (...) first but are now second. Jonathan Jenkins Ichikawa has recently proposed that we understand justification in terms of potential knowledge. Ichikawa combines his view of knowledge and justification with what initially seems to be a natural complement, epistemological disjunctivism. While Ichikawa focuses on hallucination, I shift the focus to illusion. I argue that the combination of justification as potential knowledge and epistemological disjunctivism entails that perceptual beliefs that arise from illusions are not justified. (shrink)

To test whether emotional empathy is linked to altered perceptions of self in relation to other and/or context, participants read one of two tragic news stories and then completed a self-report empathy measure, as well as an abridged version of Hood’s Mysticism scale either before or after the article. Exposure to a needy other in the story tended to result in greater self-reported mystical experience. Men with a history of mystical experience reported more empathy, but the latter was disconnected from (...) on-line reports of mystical experience. Women’s history of mystical experience did not predict empathic responding overall, but their reported empathy was linked to on-line experiences of oneness, absorption into something larger, and space-time distortion with imputed religious significance. Directions for future research, including the possible facilitative role of oxytocin, are discussed. (shrink)

The literature on coordination within and between individuals is reviewed, with an emphasis on the inherent transience of coordination patterns in behavioral activity. This transience is integral to understanding cognitive activity as flexible patterns of coordination in brain, body, and environment. Kello reviews the articles in this special issue as contributions to understanding the role of context in shaping or interpreting coordination patterns in human behavior.

This article explores four topics raised by Eyal Zamir and Barak Medina's treatment of constrained deontology. First, it examines whether mathematical threshold functions are the proper way to think about limits on deontology, given the discontinuities of our moral judgments and the desired phenomenology of rule-following. Second, it asks whether constrained deontology is appropriate for public as well as private decision-making, taking issue with the book's conclusion that deontological options are inapplicable to public decision-making, whereas deontological constraints are applicable. Third, (...) it examines the issue of the relationship between deontology and efficiency, asking whether deontological constraints should yield in situations where everyone would expect to benefit from their suspension, either ex ante or ex post . Finally, the article concludes that constrained deontology is susceptible to political abuse because of the many degrees of freedom involved in identifying constrained actions and the point at which those constraints yield to consequentialist benefits. (shrink)

Many have claimed that ceteris paribus (CP) laws are a quite legitimate feature of scientific theories, some even going so far as to claim that laws of all scientific theories currently on offer are merely CP. We argue here that one of the common props of such a thesis, that there are numerous examples of CP laws in physics, is false. Moreover, besides the absence of genuine examples from physics, we suggest that otherwise unproblematic claims are rendered untestable by the (...) mere addition of the CP operator. Thus, “CP all Fs are Gs” when read as a straightforward statement of fact, cannot be the stuff of scientific theory. Rather, we suggest that when ``ceteris paribus'' appears in scientific works it plays a pragmatic role of pointing to more respectable claims. (shrink)

Name der Zeitschrift: Das Mittelalter Jahrgang: 21 Heft: 1 Seiten: 145-158.

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and (...) made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

We discuss two problems for a general scientific understanding of language, sequences and synergies: how language is an intricately sequenced behavior and how language is manifested as a multidimensionally structured behavior. Though both are central in our understanding, we observe that the former tends to be studied more than the latter. We consider very general conditions that hold in human brain evolution and its computational implications, and identify multimodal and multiscale organization as two key characteristics of emerging cognitive function in (...) our species. This suggests that human brains, and cognitive function specifically, became more adept at integrating diverse information sources and operating at multiple levels for linguistic performance. We argue that framing language evolution, learning, and use in terms of synergies suggests new research questions, and it may be a fruitful direction for new developments in theory and modeling of language as an integrated system. (shrink)

Both in the pre-war and the post-war period right-wing extremism was not very strong in Britain. Historians, political scientist and politicians have suggested a whole range of elements to explain this failure. In the light of this limited success the victory of the British National Party in an election of the Millwall district in the London Bourough of Tower Hamlets was indeed a surprise. lt raised the question whether this was the beginning of something similar to what happened earlier in (...) France, Germany, Belgium and the Netherlands. The very specific characteristics of the London East End and ofthe Millwall district in particular make the BNP victory however quite exceptional, and do not enable a generalization of the phenomenon. This is supported by the electoral results for the London Borough and District Council of May 5 1994. Yet one can still argue that the specific danger of the BNP is not its electoral potential, but the impact of its local activities on the relations between the ethnic groups in the neighbourhoods where it is present. (shrink)

There is an apparent problem stemming from the factivity of knowledge that seems to afflict both contextualism and subject-sensitive invariantism . 1 In this article, we will first explain how the problem arises for each theory, and then we will propose a uniform resolution.1. The factivity problem for contextualismLet K t stands for X knows _ at t. Let h stand for S has hands. According to contextualism, ‘K t’ is true as uttered in some ordinary conversational contexts. Let O (...) be such a context. So we have ‘K t’ is true in O.Consider a demanding conversational context D . Let S* be a participant in D. We have ‘K t’ is not true in D.In prose: ‘S* knows at t that S has hands’ is not true in D. 2 , 3 Let us suppose that S* has a favourable epistemic status with respect to , as follows: ‘K t[S*,‘K t’ is true in O]’ is true in D. says that a certain sentence about S*'s epistemic status at t is true in D. S*'s epistemic status with respect to which proposition? A certain metalinguistic proposition concerning the truth in O of the sentence ‘K t’. That sentence in turn concerns S's epistemic status at t with respect to the proposition that S has hands. Got it? 4The factivity of ‘knows’ yields the following consequence : ‘K t’ is true in O → hThis metalinguistic factivity claim is licensed by the fact that any sentence of the …. (shrink)

The forms of words as they appear in text and speech are central to theories and models of lexical processing. Nonetheless, current methods for simulating their learning and representation fail to approach the scale and heterogeneity of real wordform lexicons. A connectionist architecture termed thesequence encoderis used to learn nearly 75,000 wordform representations through exposure to strings of stress‐marked phonemes or letters. First, the mechanisms and efficacy of the sequence encoder are demonstrated and shown to overcome problems with traditional slot‐based (...) codes. Then, two large‐scale simulations are reported that learned to represent lexicons of either phonological or orthographic wordforms. In doing so, the models learned the statistics of their lexicons as shown by better processing of well‐formed pseudowords as opposed to ill‐formed (scrambled) pseudowords, and by accounting for variance in well‐formedness ratings. It is discussed how the sequence encoder may be integrated into broader models of lexical processing. (shrink)